Pharmacological properties of Annona muricata as an alternative therapy in cancer treatment: Systematic review
DOI:
https://doi.org/10.15359/ru.38-1.29Keywords:
Annona muricata, annonaceae, alternative therapy, cytotoxic activity, flavonoids, acetogenins, apoptosis, bioactive compoundsAbstract
[Objective] The objective was to determine the pharmacological and therapeutic properties of Annona muricata as an alternative or preventive therapy for cancer treatment. [Methodology] A systematic search was conducted in 3 databases (Scopus, Pubmed/MEDLINE, and Web of Science) using keywords and controlled vocabularies on Annona muricata, alternative or preventive therapy, and cancer treatment, following the methodology of the PRISMA statement. After the initial search, selected studies were exported to Mendeley as the bibliographic reference manager. Excel and a reference form were used for data extraction of the included studies. [Results] Ten studies were selected, which evidenced the pharmacological effect of Annona muricata leaf extracts on various cancer cells. All the selected studies corresponded to in vitro/in vivo assays. In addition, the studies demonstrated the presence of several bioactive compounds present in Annona muricata, which confer cytotoxic and anticarcinogenic power. [Conclusions] This systematic review showed that Annona muricata is a plant with excellent anticancer and cytotoxic potential to be used as an alternative or complementary therapy in various types of cancer because it has bioactive compounds such as acetogenins, phenolic compounds, flavonoids, and alkaloids, whose main effect is the apoptosis of cancer cells. However, further studies, mainly intervention studies, are required to prove its effectiveness to benefit human health.
References
Adewole, S. O. y Ojewole, J. A. O. (2009). Protective effects of Annona muricata Linn. (Annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of streptozotocin-treated diabetic rats. African Journal of Traditional, Complementary and Alternative Medicines, 6(1). https://doi.org/10.4314/ajtcam.v6i1.57071
Alali, F. Q., Liu, X. X. y McLaughlin, J. L. (1999). Annonaceous acetogenins: Recent progress. Journal of Natural Products, 62(3), 504-540. https://doi.org/10.1021/np980406d
Anaya-Esparza, L. M., García-Magaña, M. de L., Abraham Domínguez-Ávila, J., Yahia, E. M., Salazar-López, N. J., González-Aguilar, G. A. y Montalvo-González, E. (2020). Annonas: Underutilized species as a potential source of bioactive compounds. Food Research International, 138(June). https://doi.org/10.1016/j.foodres.2020.109775
Asare, G. A., Afriyie, D., Ngala, R. A., Abutiate, H., Doku, D., Mahmood, S. A. y Rahman, H. (2015). Antiproliferative activity of aqueous leaf extract of Annona muricata L. on the prostate, BPH-1 cells, and some target genes. Integrative Cancer Therapies, 14(1). https://doi.org/10.1177/1534735414550198
Badrie, N. y Schauss, A. G. (2010). Soursop (Annona muricata L.): Composition, nutritional value, medicinal uses, and toxicology. Bioactive Foods in Promoting Health, January, 621-643. https://doi.org/10.1016/B978-0-12-374628-3.00039-6
Bento, E. B., Matias, E. F. F., Brito, F. E., Oliveira, D. R., Coutinho, H. D. M., Costa, J. G. M., Kerntopf, M. R. y Menezes, I. R. A. (2013). Association between food and drugs: Antimicrobial and synergistic activity of Annona muricata L. International Journal of Food Properties, 16(4), 738-744. https://doi.org/10.1080/10942912.2011.565905
Bermejo, A., Figadère, B., Zafra-Polo, M. C., Barrachina, I., Estornell, E. y Cortes, D. (2005). Acetogenins from annonaceae: Recent progress in isolation, synthesis and mechanisms of action. Natural Product Reports, 22(2), 269-303. https://doi.org/10.1039/b500186m
Bories, C., Loiseau, P., Cortes, D., Myint, S. H., Hocquemiller, R., Gayral, P., Cave, A. y Laurens, A. (1991). Antiparasitic activity of Annona muricata and Annona cherimolia seeds. Planta Medica, 57(5). https://doi.org/10.1055/s-2006-960143
Campos, L. M., de Oliveira Lemos, A. S., de Lima Paula, P., da Rocha, V. N., de Freitas Araújo, M. G., Tavares, G. D., Barradas, T. N., Nascimento, W. W. G., Denadai, A. M. L., de Oliveira, L. F. C. y Fabri, R. L. (2024). Exploring the antifungal potential of Annona muricata leaf extract-loaded hydrogel in treating vulvovaginal candidiasis. Colloids and Surfaces B: Biointerfaces, 238(April). https://doi.org/10.1016/j.colsurfb.2024.113919
Chamcheu, J. C., Rady, I., Chamcheu, R. C. N., Siddique, A. B., Bloch, M. B., Mbeumi, S. B., Babatunde, A. S., Uddin, M. B., Noubissi, F. K., Jurutka, P. W., Liu, Y. Y., Spiegelman, V. S., Whitfield, G. K. y El Sayed, K. A. (2018). Graviola (Annona muricata) exerts anti-proliferative, anti-clonogenic and pro-apoptotic effects in human non-melanoma skin cancer UW-BCC1 and A431 cells in vitro: Involvement of hedgehog signaling. International Journal of Molecular Sciences, 19(6). https://doi.org/10.3390/ijms19061791
Chang, F. R., Liaw, C. C., Lin, C. Y., Chou, C. J., Chiu, H. F. y Wu, Y. C. (2003). New adjacent bis-tetrahydrofuran annonaceous acetogenins from Annona muricata. Planta Medica, 69(3). https://doi.org/10.1055/s-2003-38485
Coria-Téllez, A. V., Montalvo-Gónzalez, E., Yahia, E. M. y Obledo-Vázquez, E. N. (2018). Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity. Arabian Journal of Chemistry, 11(5), 662-691. https://doi.org/10.1016/j.arabjc.2016.01.004
Correa Gordillo, J., Ortiz, D., Larrahondo, J. E., Sánchez Mejía, M. y Pachón, H. (2012). Actividad antioxidante en guanábana (Annona muricata L.). Boletín Latinoamericano y Del Caribe de Plantas Medicinales y Aromaticas, 11(2), 111-126. http://www.redalyc.org/articulo.oa?id=85622734002
de Sousa, O. V., Vieira, G. D. V., de Pinho, J. de J. R. G., Yamamoto, C. H. y Alves, M. S. (2010). Antinociceptive and anti-inflammatory activities of the ethanol extract of Annona muricata L. leaves in animal models. International Journal of Molecular Sciences, 11(5). https://doi.org/10.3390/ijms11052067
Escobar-Khondiker, M., Höllerhage, M., Muriel, M. P., Champy, P., Bach, A., Depienne, C., Respondek, G., Yamada, E. S., Lannuzel, A., Yagi, T., Hirsch, E. C., Oertel, W. H., Jacob, R., Michel, P. P., Ruberg, M. y Höglinger, G. U. (2007). Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons. Journal of Neuroscience, 27(29). https://doi.org/10.1523/JNEUROSCI.1644-07.2007
Fakudze, N. T., Sarbadhikary, P., George, B. P. y Abrahamse, H. (2023). Ethnomedicinal Uses, Phytochemistry, and Anticancer Potentials of African Medicinal Fruits: A Comprehensive Review. Pharmaceuticals, 16(8), 1117. https://doi.org/10.3390/ph16081117
Ferlay, J., Colombet, M., Soerjomataram, I., Parkin, D. M., Piñeros, M., Znaor, A. y Bray, F. (2021). Cancer statistics for the year 2020: An overview. International Journal of Cancer, 149(4), 778-789. https://doi.org/10.1002/ijc.33588
Gavamukulya, Y., Wamunyokoli, F. y El-Shemy, H. A. (2017). Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pacific Journal of Tropical Medicine, 10(9), 835-848. https://doi.org/10.1016/j.apjtm.2017.08.009
George, V. C., Kumar, D. R. N., Suresh, P. K. y Kumar, R. A. (2015). Antioxidant, DNA protective efficacy and HPLC analysis of Annona muricata (soursop) extracts. Journal of Food Science and Technology, 52(4). https://doi.org/10.1007/s13197-014-1289-7
Hadisaputri, Y. E., Habibah, U., Abdullah, F. F., Halimah, E., Mutakin, M., Megantara, S., Abdulah, R. y Diantini, A. (2021). Antiproliferation activity and apoptotic mechanism of soursop (Annona muricata l.) leaves extract and fractions on mcf7 breast cancer cells. Breast Cancer: Targets and Therapy, 13, 447-457. https://doi.org/10.2147/BCTT.S317682
Hamid, R. A., Foong, C. P., Ahmad, Z.y Hussain, M. K. (2012). Antinociceptive and anti-ulcerogenic activities of the ethanolic extract of Annona muricata leaf. Revista Brasileira de Farmacognosia, 22(3). https://doi.org/10.1590/S0102-695X2012005000001
Higgins, J. P. T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M. J. y Welch, V. A. (2019). Cochrane handbook for systematic reviews of interventions. En Cochrane Handbook for Systematic Reviews of Interventions. https://doi.org/10.1002/9781119536604
Höllerhage, M., Rösler, T. W., Berjas, M., Luo, R., Tran, K., Richards, K. M., Sabaa-Srur, A. U., Maia, J. G. S., Moraes, M. R. De, Godoy, H. T., Höglinger, G. U. y Smith, R. E. (2015). Neurotoxicity of Dietary Supplements from Annonaceae Species. International Journal of Toxicology, 34(6). https://doi.org/10.1177/1091581815602252
Igney, F. H. y Krammer, P. H. (2002). Death and anti-death: Tumour resistance to apoptosis. En Nature Reviews Cancer (Vol. 2, Issue 4). https://doi.org/10.1038/nrc776
Ishola, I. O., Awodele, O., Olusayero, A. M. y Ochieng, C. O. (2014). Mechanisms of analgesic and anti-inflammatory properties of annona muricata linn. (Annonaceae) fruit extract in rodents. Journal of Medicinal Food, 17(12). https://doi.org/10.1089/jmf.2013.0088
Jacobo-Herrera, N., Pérez-Plasencia, C., Castro-Torres, V. A., Martínez-Vázquez, M., González-Esquinca, A. R. y Zentella-Dehesa, A. (2019). Selective Acetogenins and Their Potential as Anticancer Agents. Frontiers in Pharmacology, 10, 447551. https://doi.org/10.3389/fphar.2019.00783
Jaramillo, M. C., Arango, G. J., González, M. C., Robledo, S. M. y Velez, I. D. (2000). Cytotoxicity and antileishmanial activity of Annona muricata pericarp. Fitoterapia, 71(2). https://doi.org/10.1016/S0367-326X(99)00138-0
Jepkorir, M., Ambundo, T., Ngule, C., Ndungu, J., Njuguna, D., Mbugua, R., Chepngetich, J. y Mwitari, P. (2018). Phytochemical Screening and in vitro Antiproliferative Activity of the Fruit of Annona muricata and Abelmoschus esculentus Pods against Selected Cancer Cell Lines. Journal of Complementary and Alternative Medical Research, 5(3). https://doi.org/10.9734/jocamr/2018/41248
Jiménez, V. M., Gruschwitz, M., Schweiggert, R. M., Carle, R. y Esquivel, P. (2014). Identification of phenolic compounds in soursop (Annona muricata) pulp by high-performance liquid chromatography with diode array and electrospray ionization mass spectrometric detection. Food Research International, 65, 42-46. https://doi.org/10.1016/j.foodres.2014.05.051
Kim, J. Y., Dao, T. T. P., Song, K., Park, S. B., Jang, H., Park, M. K., Gan, S. U. y Kim, Y. S. (2018). Annona muricata Leaf Extract Triggered Intrinsic Apoptotic Pathway to Attenuate Cancerous Features of Triple Negative Breast Cancer MDA-MB-231 Cells. Evidence-Based Complementary and Alternative Medicine, 2018. https://doi.org/10.1155/2018/7972916
Kossouoh, C., Moudachirou, M., Adjakidje, V., Chalchat, J. C. y Figuérédo, G. (2007). Essential oil chemical composition of annona muricata l. leaves from Benin. Journal of Essential Oil Research, 19(4). https://doi.org/10.1080/10412905.2007.9699288
Lannuzel, A., Michel, P. P., Caparros-Lefebvre, D., Abaul, J., Hocquemiller, R. y Ruberg, M. (2002). Toxicity of annonaceae for dopaminergic neurons: Potential role in atypical parkinsonism in Guadeloupe. Movement Disorders, 17(1), 84-90. https://doi.org/10.1002/mds.1246
Leal, F. y Paull, R. E. (2023). The soursop (Annona muricata): Botany, horticulture, and utilization. Crop Science, 63(2), 362-389. https://doi.org/10.1002/csc2.20894
Li, C. M., Tan, N. H., Zheng, H. L., Mu, Q., Hao, X. J., He, Y. N. y Zou, J. (1998). Cyclopeptide from the seeds of Annona muricata. Phytochemistry, 48(3). https://doi.org/10.1016/S0031-9422(98)00002-8
Li, D. Y., Yu, J. G., Zhu, J. X., Yu, D. L., Luo, X. Z., Sun, L. y Yang, S. L. (2001). Annonaceous acetogenins of the seeds from Annona muricata. Journal of Asian Natural Products Research, 3(4). https://doi.org/10.1080/10286020108040366
Liaw, C. C., Chang, F. R., Lin, C. Y., Chou, C. J., Chiu, H. F., Wu, M. J. y Wu, Y. C. (2002). New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona muricata. Journal of Natural Products, 65(4). https://doi.org/10.1021/np0105578
Liu, N., Yang, H. L., Wang, P., Lu, Y. C., Yang, Y. J., Wang, L. y Lee, S. C. (2016). Functional proteomic analysis revels that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway. Journal of Ethnopharmacology, 189, 210-217. https://doi.org/10.1016/j.jep.2016.05.045
Matsushige, A., Matsunami, K., Kotake, Y., Otsuka, H. y Ohta, S. (2012). Three new megastigmanes from the leaves of Annona muricata. Journal of Natural Medicines, 66(2). https://doi.org/10.1007/s11418-011-0583-1
López-Mártir, K. U., Armando Ulloa, J., Urías-Silvas, J. E., Rosas-Ulloa, P., Ramírez-Ramírez, J. C. y Resendiz-Vazquez, J. A. (2024). Modification of the physicochemical, functional, biochemical and structural properties of a soursop seed (Annona muricata L.) protein isolate treated with high-intensity ultrasound. Ultrasonics Sonochemistry, 105(April). https://doi.org/10.1016/j.ultsonch.2024.106870
Merlín-Lucas, V., Ordoñez-Razo, R. M., Calzada, F., Solís, A., García-Hernández, N., Barbosa, E. y Valdés, M. (2021). Antitumor potential of Annona muricata linn. An edible and medicinal plant in mexico: In vitro, in vivo, and toxicological studies. Molecules, 26(24). https://doi.org/10.3390/molecules26247675
Moghadamtousi, S. Z., Fadaeinasab, M., Nikzad, S., Mohan, G., Ali, H. M. y Kadir, H. A. (2015a). Annona muricata (Annonaceae): A review of its traditional uses, isolated acetogenins and biological activities. International Journal of Molecular Sciences, 16(7), 15625-15658. https://doi.org/10.3390/ijms160715625
Moghadamtousi, S. Z., Kadir, H. A., Paydar, M., Rouhollahi, E. y Karimian, H. (2014). Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB. BMC Complementary and Alternative Medicine, 14(1). https://doi.org/10.1186/1472-6882-14-299
Moghadamtousi, S. Z., Rouhollahi, E., Karimian, H., Fadaeinasab, M., Firoozinia, M., Abdulla, M. A. y Kadir, H. A. (2015b). The chemopotential effect of Annona muricata leaves against azoxymethane-induced colonic aberrant crypt foci in rats and the apoptotic effect of acetogenin annomuricin e in HT-29 cells: A bioassay-guided approach. PLoS ONE, 10(4). https://doi.org/10.1371/journal.pone.0122288
Moher, D., Liberati, A., Tetzlaff, J. y Altman, D. G. (2009). Reprint-Preferred Reporting items for systematic reviews and meta-analyses: The PRISMA statement. Physical Therapy, 89(9). https://doi.org/10.1093/ptj/89.9.873
Mutakin, M., Fauziati, R., Fadhilah, F. N., Zuhrotun, A., Amalia, R. y Hadisaputri, Y. E. (2022). Pharmacological activities of soursop (Annona muricata Lin.). Molecules, 27(4), 1201. https://doi.org/10.3390/molecules27041201
Nayak, A. y Hegde, K. (2021). A comprehensive review on the miracle nature of Annona muricata Linn. RGUHS Journal of Pharmaceutical Sciences, 11(1). https://doi.org/10.26463/rjps.11_1_6
Nawwar, M., Ayoub, N., Hussein, S., Hashim, A., El-Sharawy, R., Wende, K., Harms, M., y Lindequist, U. (2012). A flavonol triglycoside and investigation of the antioxidant and cell stimulating activities of Annona muricata Linn. Archives of Pharmacal Research, 35(5), 761-767. https://doi.org/10.1007/s12272-012-0501-4
Nolasco-González, Y., Chacón-López, M. A., Ortiz-Basurto, R. I., Aguilera-Aguirre, S., González-Aguilar, G. A., Rodríguez-Aguayo, C. y Montalvo-González, E. (2022). Annona muricata leaves as a source of bioactive compounds: Extraction and quantification using ultrasound. Horticulturae, 8(7), 560. https://doi.org/10.3390/horticulturae8070560
Okada, H. y Mak, T. W. (2004). Pathways of apoptotic and non-apoptotic death in tumour cells. Nature Reviews Cancer (Vol. 4, Issue 8). https://doi.org/10.1038/nrc1412
Olas, B. (2023). The Antioxidant Potential of Graviola and Its Potential Medicinal Application. Nutrients, 15(2). https://doi.org/10.3390/nu15020402
Osorio, E., Arango, G. J., Jiménez, N., Alzate, F., Ruiz, G., Gutiérrez, D., Paco, M. A., Giménez, A. y Robledo, S. (2007). Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae. Journal of Ethnopharmacology, 111(3). https://doi.org/10.1016/j.jep.2007.01.015
Padma, P., Pramod, N. P., Thyagarajan, S. P. y Khosa, R. L. (1998). Effect of the extract of Annona muricata and Petunia nyctaginiflora on Herpes simplex virus. Journal of Ethnopharmacology, 61(1). https://doi.org/10.1016/S0378-8741(98)00013-0
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., … Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. PLoS Medicine. https://doi.org/10.1371/JOURNAL.PMED.1003583
Passos, T. U., Sampaio, H. A. de C., Sabry, M. O. D., de Melo, M. L. P., Coelho, M. A. M., y Lima, J. W. de O. (2015). Glycemic index and glycemic load of tropical fruits and the potential risk for chronic diseases. Food Science and Technology (Brazil), 35(1). https://doi.org/10.1590/1678-457X.6449
Pélissier, Y., Marion, C., Kone, D., Lamaty, G., Menut, C. y Bessière, J. M. (1994). Volatile components of Annona muricata L. Journal of Essential Oil Research, 6(4). https://doi.org/10.1080/10412905.1994.9698410
Pieme, A. A., Kumar, G. G., Dongmo, S. S., Moukette, M. M., Boyoum, F. F., Ngogang, Y. Y. y Saxena, K. K. (2014). Antiproliferative activity and induction of apoptosis by Annona muricata (Annonaceae) extract on human cancer cells. BMC Complementary and Alternative Medicine, 14(1). https://doi.org/10.1186/1472-6882-14-516
Pinto, A. C. Q., Cordeiro, M. C. R., Andrade, S. R. M.., Ferreira, F. R., Filgueiras, H. A. C., Alves, R. E. y Kinpara, D. I. (2005). Annona Species. En J. T. Williams (Ed.), Annona species (Vol. 1, Issue 1). https://assets.publishing.service.gov.uk/media/57a08c6640f0b652dd0012e6/R7187_-_Annona_monograph_-_revised.pdf
Prasad, S. K., Varsha, V. y Devananda, D. (2019). Anti-cancer properties of Annona muricata (L.): A Review. Medicinal Plants, 11(2), 123-134. https://doi.org/10.5958/0975-6892.2019.00016.9
Prasad, S. K., Veeresh, P. M., Ramesh, P. S., Natraj, S. M., Madhunapantula, S. R. V. y Devegowda, D. (2020). Phytochemical fractions from Annona muricata seeds and fruit pulp inhibited the growth of breast cancer cells through cell cycle arrest at G0/G1phase. Journal of Cancer Research and Therapeutics, 16(6). https://doi.org/10.4103/jcrt. JCRT_494_19
Qorina, F., Arsianti, A., Fithrotunnisa, Q., Tejaputri, N. A., Azizah, N. N. y Putrianingsih, R. (2020). Cytotoxicity of soursop leaves (Annona muricata) against cervical HeLa cancer cells. Pharmacognosy Journal, 12(1), 20-24. https://doi.org/10.5530/pj.2020.12.4
Quílez, A. M., Fernández-Arche, M. A., García-Giménez, M. D. y De la Puerta, R. (2018). Potential therapeutic applications of the genus Annona: Local and traditional uses and pharmacology. Journal of Ethnopharmacology, 225, 244-270. https://doi.org/10.1016/j.jep.2018.06.014
Rady, I., Bloch, M. B., Chamcheu, R. C. N., Banang Mbeumi, S., Anwar, M. R., Mohamed, H., Babatunde, A. S., Kuiate, J. R., Noubissi, F. K., El Sayed, K. A., Whitfield, G. K. y Chamcheu, J. C. (2018). Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review. Oxidative Medicine and Cellular Longevity, 2018. https://doi.org/10.1155/2018/1826170
Ragasa, C. Y., Soriano, G., Torres, O. B., Don, M. J., y Shen, C. C. (2012). Acetogenins from Annona muricata. Pharmacognosy Journal, 4(32), 32–37. https://doi.org/10.5530/pj.2012.32.7
Roslida, A. H., Tay, C. E., Zuraini, A. y Chan, P. F. (2010). Anti-inflammatory and anti-nociceptive activities of the ethanolic extract of Annona muricata leaf. Journal of Natural Remedies, 10(2).
Salawu, O. A., Chindo, B. A., Tijani, A. Y., Obidike, I. C., Salawu, T. A. y Akingbasote, A. J. (2009). Acute and sub-acute toxicological evaluation of the methanolic stem bark extract of Crossopteryx febrifuga in rats. African Journal of Pharmacy and Pharmacology, 3(12).
Santos, I. L., Rodrigues, A. M. D. C., Amante, E. R. y Silva, L. H. M. D. (2023). Soursop (Annona muricata) properties and perspectives for integral valorization. Foods, 12(7), 1448. https://doi.org/10.3390/foods12071448
Solomon-Wisdom, Ugoh, S. C. y Mohammed. (2014). Phytochemical Screening and Antimicrobial activities of Annona muricata (L) leaf extract. American Journal of Biological, Chemical and Pharmaceutical Sciences, 2(1), 01-07.
Sozen, E., Karademir, B. y Ozer, N. K. (2015). Basic mechanisms in endoplasmic reticulum stress and relation to cardiovascular diseases. Free Radical Biology and Medicine,, 78. https://doi.org/10.1016/j.freeradbiomed.2014.09.031
Sun, S., Liu, J., Sun, X., Zhu, W., Yang, F., Felczak, L., Ping Dou, Q. y Zhou, K. (2017). Novel Annonaceous acetogenins from Graviola (Annona muricata) fruits with strong anti-proliferative activity. Tetrahedron Letters, 58(19), 1895-1899. https://doi.org/10.1016/j.tetlet.2017.04.016
Syed Najmuddin, S. U. F., Romli, M. F., Hamid, M., Alitheen, N. B. y Abd Rahman, N. M. A. N. (2016). Anti-cancer effect of Annona Muricata Linn Leaves Crude Extract (AMCE) on breast cancer cell line. BMC Complementary and Alternative Medicine, 16(1), 1-20. https://doi.org/10.1186/s12906-016-1290-y
Tait, S. W. G. y Green, D. R. (2010). Mitochondria and cell death: Outer membrane permeabilization and beyond. Nature Reviews Molecular Cell Biology, 11(9). https://doi.org/10.1038/nrm2952
Takahashi, S., Hongo, Y., Tsukagoshi, Y. y Koshino, H. (2008). Structural determination of montanacin D by total synthesis. Organic Letters, 10(19). https://doi.org/10.1021/ol801576z
Vieira, G. H. F., Mourão, J. A., Ângelo, Â. M., Costa, R. A. y Vieira, R. H. S. dos F. (2010). Antibacterial effect (in vitro) of moringa oleifera and annona muricata against gram positive and gram negative bacteria. Revista Do Instituto de Medicina Tropical de Sao Paulo, 52(3). https://doi.org/10.1590/S0036-46652010000300003
Wélé, A., Ndoye, I. y Badiane, M. (2005). Fatty Acid And Essential Oil Compositions Of The Seed Oil Of Five Annona Species. Nigerian Journal of Natural Products and Medicine, 8(1). https://doi.org/10.4314/njnpm.v8i1.11819
Wu, F. E., Zhao, G. X., Zeng, L., Zhang, Y., Schwedler, J. T., McLaughlin, J. L. y Sastrodihardjo, S. (1995). Additional bioactive acetogenins, annomutacin and (2,4-trans and cis-10r-annonacin-a-ones, from the leaves of annona muricata. Journal of Natural Products, 58(9). https://doi.org/10.1021/np50123a015
Yajid, A. I., Ab Rahman, H. S., Wong, M. P. K. y Wan Zain, W. Z. (2018). Potential benefits of Annona muricata in combating cancer: A review. Malaysian Journal of Medical Sciences, 25(1), 5-15. https://doi.org/10.21315/mjms2018.25.1.2
Zafra-Polo, M. C., González, M. C., Estornell, E., Sahpaz, S. y Cortes, D. (1996). Acetogenins from annonaceae, inhibitors of mitochondrial complex I. Phytochemistry, 42(2),253-271. https://doi.org/10.1016/0031-9422(95)00836-5
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