The horse as a model for translational orthopedic research: examples of studies on the regeneration of cartilage and bone conducted in Costa Rica
DOI:
https://doi.org/10.15359/rcv.37-3.2Abstract
The paper provides results published or to be published of long-term in vivo equine studies to evaluate techniques of possible regenerative matrices of cartilage and bone, by means of cell-free implants or stimulation of the bone marrow. From the fixation techniques analyzed, it can be concluded that the best alternatives are the pressure technique for subchondral defects and a novel hydrogel with self-adhesive capacity for chondral defects.
The equine coxal tuberosity was used for the first time as a model for regeneration studies of bone defects, analyzing scaffolds based on tricalcium phosphate, polymers and nanoparticles, by means of 3-D printing. Osteoconductivity, osteoinductivity, and the importance of microporosity were documented.
Given that decellularized materials do not always give significant desired results in the regeneration of cartilage, it is important to conduct long-term studies. The technique of nanofracture and a novel self-adhesive hydrogel in the knee of the equine showed promising preliminary results in the regeneration of cartilage.
The knee and the coxal tuberosity of the horse represent models of studying cartilage and bone regeneration in a true translational sense as a source of highly valuable information for clinical studies, for both horses and humans.
References
Mancini I.A.D., Vindas, R.A., Brommer, H., Castilho, M., Ribeiro, A., van Loon, J.P.A.M., Mensinga, A., van Rijen, M.H.P., Malda, J. & van Weeren, P.R. 2017. Fixation of hydrogel constructs for cartilage repair in the equine model: a challenging issue. Tiss. Eng. Part C. Methods 8(11): 804-814. DOI: 10.1089/ten.TEC.2017.0200.
Vindas-Bolaños, R.A., Cokelaere, S.M., Estrada McDermott, J.M., Benders, K., E.M., Gbureck, U., Plomp, S.G.M., Weinans, H., Groll, J., van Weeren, P.R., Malda, J., 2017. The use of cartilage decellularized matrix scaffold for the repair of osteochondral defects: the importance of long-term studies in large animal model. Osteoarthritis and Cartilage 25: 413-420. DOI.org/10.1016/j.joca.2016.08.005
Vindas-Bolaños, R.A. 2019. PhD diss. Cell-free regenerative medicine (RM) strategies for cartilage and bone put to the test in the challenging equine in vivo model. Utrecht University, Netherlands.
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