Equine Histiocytic Non-epitheliotropic Cutaneous Lymphoma (T-cell Rich B-Cell Lymphoma): Report of a Clinical Case
DOI:
https://doi.org/10.15359/rcv.39-1.4Keywords:
equine lymphoma, B-cells, T-cells, histiolymphocytic, Costa RicaAbstract
An adult, Ibero breed, equine gelding, with a clinical history of “several ulcers and inflammations all over the body, plus a chronic loss of condition” is attended. The farm veterinarian sent biopsy samples to a private pathology laboratory and referred the horse to the Equine Hospital, School of Veterinary Medicine, at the Universidad Nacional de Costa Rica. While the patient was hospitalized, the results from the private pathologist were received, and a diagnosis of “equine histiocytic non-epitheliotropic cutaneous lymphoma” was made. The horse was humanely euthanized, and the body was examined at the Department of Pathology. Necropsy reports the most relevant macroscopic & microscopic findings and confirms the diagnosis of “T-cell rich B-cell lymphoma (histiolymphocytic cutaneous lymphoma).” The histopathological results from examining several organs of the patient showed the presence of an abundant mononuclear infiltrate composed of lymphocytes, histiocytes, and some plasmatic cells. Considering that dermatological pathologies are amongst the first two groups of diseases affecting horses, it is of paramount importance to include this disease in the differential diagnosis.
References
Bacci, B., Stent, A.W., Walmsley, E.A. (2020). Equine Intestinal Lymphoma: Clinical-Pathological Features, Immunophenotype and Survival. Veterinary Pathology, 57(3): 369-376. https://doi.org/10.1177/0300985820906889.
de Bruijn, C.M., Veenman, J.N., Rutten, E.T., van Nieuwstadt, R.A. & van den Ingh, T.S. (2007). Clinical, histopathological and inmunophenotypical findings in five horses with cutaneous malignant lymphoma. Research Veterinary Science, 83(1): 63-72. https://doi.org/10.1016/j.rvsc.2006.10.015.
de Clercq, D., van Loon, G., Lefère, L., Deprez, P. (2004). Ultrasound-guided biopsy as a diagnostic aid in three horses with a cranial mediastinal lymphosarcoma. Veterinary Record, 5;154(23):722-6. https://doi.org/10.1136/vr.154.23.722.
Duran, M.C., Starrak, G., Dickinson, R. & Montgomery, J. (2016). Peritoneal fluid immunocytochemistry used for the diagnosis of a possible case of equine gastrointestinal B-cell lymphoma. Canadian Veterinary Journal, 57(6): 601-604. PMID: 27247458; PMCID: PMC4866663.
Durham, A.C., Pillitteri, C.A., San Myint, M. & Valli, V.E. (2013). Two hundred three cases of equine lymphoma classified according to the World Health Organization (WHO) classification criteria. Veterinary Pathology, 50(1): 86-93. https://doi.org/10.1177/0300985812451603.
Garber, J. L. , Reef , V. B., Reimer, J. M. (1994). Sonographic findings in horses with mediastinal lymphosarcoma: 13 cases (1985-1992). Journal American Veterinary Medical Association, 205(10):1432-6. PMID: 7698925
Henson, K.L., Alleman, A.R., Kelley, L.C. & Mahaffey, E.A. (2000). Immunohistochemical characterization of estrogen and progesterone receptors in lymphoma of Horses. Veterinary Clinical Pathology, 29(2): 40-46. https://doi.org/10.1111/j.1939-165X.2000.tb00396.x.
Janvier, V., Evrard, L., Cerri, S., Gougnard, A., Busoni,V. (2016). Ultrasonographic findings in 13 horses with lymphoma. Veterinary Radiology Ultrasound, 57(1):65-74. https://doi.org/10.1111/vru.12302.
Kelley, L.C & Mahaffey, E.A. (1998). Equine malignant lymphomas: morphologic and immunohistochemical classification. Veterinary Pathology, 35(4): 241-252. https://doi.org/10.1177/030098589803500402.
Knottenbelt, D.C., Patterson-Kane, J.C. & Snalune, K.L. (2015). Clinical Equine Oncology. Elsevier. Edinburg. p.342- 362.
Knowles, E.J., Tremaine, W. H., Pearson, G. R., Mair, T.S. (2016). A database survey of equine tumours in the United Kingdom. Equine Veterinary Journal, 48(3):280-4. https://doi.org/10.1111/evj.12421
Larsdotter, S., Nostell, K., von Euler, H. (2015). Serum thymidine kinase activity in clinically healthy and diseased horses: a potential marker for lymphoma. Veterinary Journal, 205(2):313-316. https://doi.org/10.1016/j.tvjl.2015.01.019.
Littlewood, J.D., Whitwell, K.E. & Day, M.J. (1995). Equine cutaneous lymphoma: a case report. Veterinary Dermatology, 6(2):105-111. https://doi.org/10.1111/j.1365-3164.1995.tb00051.x
Luethy, D., Frimberger, A.E., Bedenice, D., Byrne, B.S., Groover, E.S., Gardner, R.B., Lewis, T., MacDonald, V.S., Proctor-Brown, L., Tomlinson, J.E., Rassnick, K.M. & Johnson, A.L. (2019). Retrospective evaluation of clinical outcome after chemotherapy for lymphoma in 15 equids (1991-2017). Journal Veterinary Internal Medicine, 33(2): 953-960. https://doi.org/10.1111/jvim.15411
Matsuda, K., Shimada, T., Kawamura, Y., Sakaguchi, K., Tagami, M., Taniyama, H.J. (2013.) Jejunal intussusception associated with lymphoma in a horse. Veterinary Medicine Science, 75(9):1253-6. https://doi.org/10.1292/jvms.13-0060.
Meisel, R., Zibert, A., Laryea, M., Gobel, U., Daubener, W. & Dilloo, D. (2004). Human bone marrow stromal cells inhibit allogenic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood, 103(12): 4619-21. https://doi.org/10.1182/blood-2003-11-3909.
Meyer, J., Delay, J. & Bienzle, D. (2006). Clinical, laboratory, and histopathologic features of equine lymphoma. Veterinary Pathology, 43(6): 914-924. https://doi.org/10.1354/vp.43-6-914.
Miglio, A., Morelli, C., Gialletti, R., Laureti, E., Sforna, M., Marenzoni, M.L. & Antognoni, M.T. (2019). Clinical and immunophenotypic findings in 4 forms of equine lymphoma. Canadian Veterinary Journal, 60(1): 33–40. PMID: 30651648; PMCID: PMC6294024.
Miller, C.A., Durham, A.C., Schaffer, P.A., Ehrhart, E.J., Powers, B.E. & Duncan, C.G. (2015). Classification and clinical features in 88 cases of equine cutaneous lymphoma. Journal Veterinary Diagnostic Investigation, 27(1): 86-91. https://doi.org/10.1177/1040638714561653.
Muñoz, A., Riber, C., Trigo, P., Castejón F. (2009). Hematopoietic Neoplasias in Horses: Myeloproliferative and Lymphoproliferative Disorders. Journal Equine Science, 20(4): 59–72. https://doi.org/10.1294/jes.20.59
Murphy, C.J., Lavoie, J.P., Groff, J., Hacker, D., Pryor, P. & Bellhorn, R.W. (1989). Bilateral eyelid swelling attributable to lymphosarcoma in a horse. Journal American Veterinary Medical Association, 194(7):939-942. PMID: 2703429
Rebhun, W.C. & Del Piero, F. (1998). Ocular lesions in horses with lymphosarcoma: 21 cases (1977-1997). Journal American Veterinary Medical Association, 212(6): 852-854. PMID: 9530426
Scott, D.W & Miller, W.H. (2010). Equine dermatology, 2nd Edition. Saunders, St. Louis.
Taintor, J. & Schleis, S. (2011). Equine lymphoma. Equine Veterinary Education, 23(4): 205-213. https://doi.org/ 10.1111/j.2042-3292.2010.00200.x
Valli, V.E., Jacobs, R.M. & Parodi, A.L. (2002). Histological classification of hematopoietic tumors of domestic animals. Armed Forces Institute of Pathology, Washington DC.
Valli, V.E. (2007). Hematopoietic system. In Jubb, K.V., Kennedy, P.C. & Palmer, N. (Eds.). Pathology of Domestic Animals. Saunders, New York. p.150-152.
Published
How to Cite
Issue
Section
License
Licensing of articles
All articles will be published under a license:
Licencia Creative Commons Atribución-NoComercial-SinDerivadas 3.0 Costa Rica.
Access to this journal is free of charge, only the article and the journal must be cited in full.
Intellectual property rights belong to the author. Once the article has been accepted for publication, the author assigns the reproduction rights to the Journal.
Ciencias Veterinarias Journal authorizes the printing of articles and photocopies for personal use. Also, the use for educational purposes is encouraged. Especially: institutions may create links to specific articles found in the journal's server in order to make up course packages, seminars or as instructional material.
The author may place a copy of the final version on his or her server, although it is recommended that a link be maintained to the journal's server where the original article is located.
Intellectual property violations are the responsibility of the author. The company or institution that provides access to the contents, either because it acts only as a transmitter of information (for example, Internet access providers) or because it offers public server services, is not responsible.